CALL FOR PAPERS Regulation of Cardiovascular Functions by Eicosanoids and Other Lipid Mediators Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin
نویسندگان
چکیده
Tomas G. Neilan, Glen A. Doherty, Gang Chen, Catherine Deflandre, Hester McAllister, Ryan K. Butler, Sarah E. McClelland, Elaine Kay, Leslie R. Ballou, and Desmond J. Fitzgerald Department of Clinical Pharmacology, Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, and Department of Surgery and Pathology, Beaumont Hospital, Dublin, Ireland; Department of Veterinary Medicine, University College Dublin, Ireland; and Department of Veterans Affairs Medical Center, Departments of Medicine and Molecular Sciences, University of Tennessee, Memphis, Tennessee
منابع مشابه
Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin.
To determine the role of cyclooxygenase (COX)-2 in anthracycline-induced cardiac toxicity, we administered doxorubicin (Dox) to mice with genetic disruption of COX-2 (COX-2-/-). After treatment with Dox, COX-2-/- mice had increased cardiac dysfunction and cardiac cell apoptosis compared with Dox-treated wild-type mice. The expression of the death-associated protein kinase-related apoptosis-indu...
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The present study was conducted to test the effect of Origanum Majoranum Extract (OME) of leaves on alterations induced in a model of type 2 diabetic rats. Adult male Wistar rats were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetic rats. Diabetic rats were given aqueous extract of OME in a dose of 20 mg/kg orally ...
متن کاملOriganum Majoranum Extract Modulates Gene Expression, Hepatic and Renal Changes in a Rat Model of Type 2 Diabetes
The present study was conducted to test the effect of Origanum Majoranum Extract (OME) of leaves on alterations induced in a model of type 2 diabetic rats. Adult male Wistar rats were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetic rats. Diabetic rats were given aqueous extract of OME in a dose of 20 mg/kg orally ...
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تاریخ انتشار 2006